ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECTS OF LYGODIUM MICROPHYLLUM IN ALLOXAN INDUCED DIABETIC RATS
By: Syahidah, Nadiah Binti Abdull Majid D. G
.
Contributor(s): Mohammad Iqbal.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2018Edition: Vol.10(12).Description: 75-79p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective
:
The antihyperglycemic and antioxidative effects of
L. microphyllum
were evaluated by using
in vivo
methods in normal and alloxan
induced diabetic rats.
Methods
:
Diabetes was induced in Sprague Dawley rats by inje
cting alloxan through intravenous (i. v) at a dose
of 100 mg/kg of body weight. Aqueous
extract of
L. microphyllum
at different doses (400, 200 and 100 mg/kg of body
weight) was administered orally (orogastric intuba
tion) for 14 d. Blood
glucose and oxidative stress markers were measured.
Hematoxylin and eosin staining method were used to
examine the pancreatic tissues.
Results:
At the 14 d interval, fasting blood glucose showed
a reduction in serum glucose levels in animals pret
reated with
L. microphyllum
compared with alloxan alone treated group. Oxidativ
e stress was noticed in rat’s pancreatic tissue as
evidenced by a significant decrease in
glutathione level, glutathione reductase, glutathio
ne-S-transferase, and catalase activities. Malondia
ldehyde showed a significant increase compared
to the normal saline-treated control group. Serum b
iochemistry and oxidative stress markers were consi
stent with the pancreatic histopathological
studies. Treatment of diabetic rats with
L. microphyllum
at a dose level of 100, 200 and 400 mg/kg body wei
ght leaves extract for 14 d significantly
prevented these alterations and attenuated alloxan-
induced oxidative stress (P<0.05).
Conclusion:
The results of the present study indicated that the
antihyperglycemic potential of
L. microphyllum
might be ascribable to its antioxidant
and free radical scavenging properties. Thus, it is
concluded that
L. microphyllum
may be helpful in the prevention of diabetic compl
ications
associated with oxidative stress.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020960 |
Objective
:
The antihyperglycemic and antioxidative effects of
L. microphyllum
were evaluated by using
in vivo
methods in normal and alloxan
induced diabetic rats.
Methods
:
Diabetes was induced in Sprague Dawley rats by inje
cting alloxan through intravenous (i. v) at a dose
of 100 mg/kg of body weight. Aqueous
extract of
L. microphyllum
at different doses (400, 200 and 100 mg/kg of body
weight) was administered orally (orogastric intuba
tion) for 14 d. Blood
glucose and oxidative stress markers were measured.
Hematoxylin and eosin staining method were used to
examine the pancreatic tissues.
Results:
At the 14 d interval, fasting blood glucose showed
a reduction in serum glucose levels in animals pret
reated with
L. microphyllum
compared with alloxan alone treated group. Oxidativ
e stress was noticed in rat’s pancreatic tissue as
evidenced by a significant decrease in
glutathione level, glutathione reductase, glutathio
ne-S-transferase, and catalase activities. Malondia
ldehyde showed a significant increase compared
to the normal saline-treated control group. Serum b
iochemistry and oxidative stress markers were consi
stent with the pancreatic histopathological
studies. Treatment of diabetic rats with
L. microphyllum
at a dose level of 100, 200 and 400 mg/kg body wei
ght leaves extract for 14 d significantly
prevented these alterations and attenuated alloxan-
induced oxidative stress (P<0.05).
Conclusion:
The results of the present study indicated that the
antihyperglycemic potential of
L. microphyllum
might be ascribable to its antioxidant
and free radical scavenging properties. Thus, it is
concluded that
L. microphyllum
may be helpful in the prevention of diabetic compl
ications
associated with oxidative stress.
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